It is important to determine the source of iron deficiency to avoid recurrence of anemia. Because a small number of red blood cells decrease the supply of oxygen to each tissue in the body, anemia can cause various signs and symptoms. It can also worsen symptoms of almost all other underlying medical conditions. If the anemia continues slowly, the body can adapt and compensate for the change; in this case, there may not be symptoms until the anemia becomes more severe. Nutritional iron deficiency is common in developing countries.

Sometimes it is difficult to diagnose the cause of iron deficiency, or your doctor may fear that there is a problem other than iron deficiency that causes anemia. These may include hereditary blood disorders called thalassemia, the red blood cells of which also resemble small pale hemoglobinopathies, such as sickle cell anemia or other blood disorders. People with chronic infections or diseases such as kidney failure, autoimmune diseases and inflammatory disorders may also have small red blood cells. When the cause of anemia is not clear, your doctor may refer you to a hematologist, a doctor of blood disorders, for further consultation and evaluation.

Macrocyte anemia can be divided into “megaloblastic anemia” or “non-megaloblastic macrocyte anemia”. The cause of megaloblastic anemia is mainly a failure of DNA synthesis with a preserved RNA synthesis, resulting in a restricted cell division of 經血過多 progenitor cells. Megaloblastic anemia often exhibits neutrophilic hypersegmentation . Non-megaloblastic macrocyte anemias have different etiologies (p. Eg. synthesis of globin DNA without deterioration,) occurring, for example, in alcoholism.

When a person has severe anemia, the cause must be determined quickly so that they can be properly treated. Your doctor will have a physical exam and ask you questions about your medical history and symptoms. These tests may include a full blood count to look at your red blood cells and an iron test that shows the amount of iron in your blood. The causes of anemia can be classified as alteration in the production of red blood cells, increased destruction of red blood cells, blood loss and water overload . The most common cause of anemia is blood loss, but this usually does not cause lasting symptoms unless the production of relatively altered red blood cells, in turn, most often due to deficiency.

The treatment of iron deficiency anemia usually involves taking iron supplements and changing your diet to increase your iron levels, as well as treating the underlying cause. If your general practitioner thinks that your anemia may be the result of a deficiency of vitamin B12 and folic acid, the levels of these substances can be analyzed. Folate works with vitamin B12 to help your body produce red blood cells. People with chronic kidney disease often develop iron deficiency anemia.

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